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KMID : 0390220000110020230
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Journal of Clinical Otolaryngology, Head and Neck Surgery
2000 Volume.11 No. 2 p.230 ~ p.236
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Expression of PCNA and Apoptoic Bodies in Nasal Inverted Papilloma
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이정훈/Jung Hoon Rhee
김경환/조강한/백상흠/홍영호/김춘길/Kyung Hwan Kim/Kang Han Cho/Sang Heum Paik/Young Ho Hong/Chun Gil Kim
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Abstract
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Background and Objectives : Inverted papilloma of the nasal cavity and paransal sinuses is uncommon
benign lesion, in which there is a inversion of the neoplastic eithelium into the underlying stroma.
Proliferating cell unclear antigen(PCNA) indicates the cellular kinetic activity during the late G1 and S phase.
Among the various approaches for evaluating the proliferative activity, PCNA has been recently introduced as
an antigenic marker of cellular proliferation. Programmed cell death(apoptosis) is distinctive from of cell
death manifested by characteristic chromatin condensation and DNA fragmentation, whose function is the
deletion of cells normal development, organogensis, immune function, and tissue growth, but which can
also be indeced by pathologic stimuli. The purpose of this study was to detect expression of PCNA and
apoptotic bodies, and to understand the mechanism of pathogenesis of nasal inverted papilloma. Materials
and Methods: Twenty-nine cases of nasal inverted papilomas, 5 squamous cell carcinomas, 10 nasal polyps
and 10 inferior turbinate mucosas were analyzed for the detection of PCAN and apoptotic bodies by
immunohistochemical techinque. Results : PCNA indices were 22.5±7.7%, 45.4±2.6%, 7.9±3.9% and 0%
in inverted papillomas, squamous cell carcinomas, nasal polyps and inferior turbinate mucosas. PCNA index of
inverted papillomas with dysplasia was higher(31.4±5.4%) than inverted papilloma without dysplasia(18.5±4.6%).
Apoptotic indices were 7.8±3.8%, 13.4%±3.5%, 0.9±1.5% and 0.4±0.8% in inverted papillomas,
squamous cell carcinomas, nasal polyps and inferior turbinate mucosas. Apoptotic index of inverted papillomas
with dysplasia was higher(10.0±3.2%) than inverted papillom without dysplasia(6.8±3.7%). Conclusion :
These results showed that cellular proliferation and apoptosis play a role in development of nasal inverted
papilloma. Also cellular proliferation is more important factor than apoptosis in development of nasal inverted
papilloma.
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